quantification of Post-Translational Modifications

Welcome to qPTM

Post-translational modifications (PTMs) are critical molecular mechanisms that regulate the protein functions temporally and spatially in almost all organisms. Since almost all PTMs are reversible and dynamic, the quantifications of PTM events under different states or conditions are also critical for understanding the biological process. With the rapid development of high-throughput proteomics technologies, massive quantitative PTM proteome datasets have been generated. Thus, a comprehensive one-stop data resource for surfing the big data will be very useful to the community.

Previously, we developed the qPhos database to host the quantitative phosphoproteome data in Homo sapiens, here we update it to qPTM database for 6 types of PTMs including acetylation, glycosylation, methylation, phosphorylation, SUMOylation, ubiquitylation in 4 different organisms including human, mouse, rat and yeast. Also, the matched proteome datasets were integrated if available. In total, 11,482,533 quantification events for 660,030 sites on 40,728 proteins under 2,596 conditions are collected and integrated in the qPTM database.